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Title:
PRODUCTION OF 4-AMINOPYRIDINE DERIVATIVE
Document Type and Number:
Japanese Patent JP3454435
Kind Code:
B2
Abstract:

PURPOSE: To obtain the subject compound useful as an intermediate for synthesizing cerebral function disorder-improving medicines by reacting an aminonitrile derivative with a ketone derivative in the presence of a strong acidic ion exchange resin and subsequently reacting the reactional product with a Lewis acid.
CONSTITUTION: A compound of formula I (A forms a five-six membered carbon ring or heterocyclic ring together with C) is reacted with a compound of formula II (B forms a five-six membered ring together with C) in the presence of a strong acidic ion exchange resin (e.g. Amberlist 15, Rohm & Haas Inc) in a solvent (e.g. 1,2-dichloroethane) at the refluxing temperature of the reaction mixture, and further reacted with a Lewis acid (e.g. anhydrous zinc chloride) preferably under an azeotropic dehydration treatment to provide the objective compound of formula III, e.g. 4-amino-2,3-dimethyl-5,6,7,8-tetrahydro-furo[2,3- b]quinoline. The compound of formula II, the catalyst and the Lewis catalyst are used in amounts of 0.5-10 equivalents, 0.1-50wt.% and 0.1-10 equivalents, respectively, based on the amount of the compound of formula I.


Inventors:
Mamoru Kanno
Haruko Harada
Yasuhiro Morinaka
Application Number:
JP6847893A
Publication Date:
October 06, 2003
Filing Date:
March 26, 1993
Export Citation:
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Assignee:
Mitsubishi Chemical Corporation
International Classes:
A61K31/00; A61P25/28; B01J31/10; C07B61/00; C07D219/10; C07D221/16; C07D471/04; C07D471/14; C07D491/048; C07D491/08; C07D491/147; C07D495/04; C07D498/04; C07D498/14; B01J27/10; (IPC1-7): C07D491/048; B01J27/10; B01J31/10; C07D219/10; C07D221/16; C07D471/04; C07D471/14; C07D491/08; C07D491/147; C07D495/04; C07D498/04; C07D498/14
Domestic Patent References:
JP3218361A
JP63166881A
JP63297367A
JP61230743A
JP4268316A
JP393778A
JP6475464A
JP63132891A
Other References:
【文献】米国特許4514570(US,A)
【文献】北条舒正・編,機能性高分子シリーズ キレート樹脂・イオン交換樹脂,株式会社講談社,第159~161、175~178頁,1977年
Attorney, Agent or Firm:
Masao Takayanagi