PURPOSE: To obtain the titled substance useful as an intermediate for a physiologically active substance, by reacting a γ-fluorocarbonyl compound with an alkali metallic amide to give an alkali metallic enolate and reacting it with an electrophilic reagent.
CONSTITUTION: A compound shown by the formula I [Rf is fluoroalkyl containing at least one F atom at 1-position; R1 is alkyl, cycloalkyl, aryl, etc.; X is -O-R2 or -R2 (R2 is alkyl, cycloalkyl, aryl, etc.)] is reacted with an alkali metallic amide to give an alkali metallic enolate shown by the formula II, which is treated with an electrophilic reagent (e.g., aliphatic ketone, aliphatic aldehyde or iodated N,N-dialkylmethylene ammonium) in a solvent such as THF, etc., preferably at ≤0°C to give a compound shown by the formula III (E is organic electrophilic reagent residue).
YASUDA ARATA
MORISAWA YOSHITOMI
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