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Title:
PRODUCTION OF FLUORINE-CONTAINING CARBONYL COMPOUND
Document Type and Number:
Japanese Patent JPS60181045
Kind Code:
A
Abstract:

PURPOSE: To produce the optically active titled compound having high optical purity, in high yield and purity, by reacting an optically active enamine with a fluorine-containing halide in the presence of a specific metal and catalyst under the action of ultrasonic wave, and treating the product with an acid.

CONSTITUTION: The objective optically active fluorine-containing carbonyl compound of formula IV (* is chiral carbon atom) is produced by (1) reacting the carbonyl compound of formula I (R1 and R2 are univalent hydrocarbon group or hetero-hydrocarbon group, or together form a bivalent hydrocarbon group or hetero-hydrocarbon group forming a ring; R3 is H or hydrocarbon group) with the optically active proline derivative of formula II (R4 is hydrocarbon group), (2) reacting the resultant optically active enamine of formula III with the fluorine-containing halide of formula RfX (Rf is fluorine-containing hydrocarbon group; X is halogen) in the presence of a metal such as zinc powder and a catalyst such as dicyclo (π-cyclopentadienyl)titanium, etc. under the action of ultrasonic vibration, and (3) treating the reaction product with an acid such as sulfuric acid.


Inventors:
ISHIKAWA NOBUO
KITATSUME TOMOYA
Application Number:
JP3837884A
Publication Date:
September 14, 1985
Filing Date:
February 29, 1984
Export Citation:
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Assignee:
DAIKIN IND LTD
International Classes:
C07C45/56; B01J19/10; B01J31/00; C07B31/00; C07B53/00; C07C45/00; C07C49/167; C07C49/233; C07C49/457; C07C49/697; C07C67/00; (IPC1-7): B01J19/10; B01J31/12; C07B53/00; C07C45/56; C07C49/167; C07C49/233; C07C49/457; C07C49/697
Attorney, Agent or Firm:
Hiroshi Osaka



 
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