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Title:
PRODUCTION OF ISOTOPE-LABELED 3,4:5,6-DI-O-ISOPROPYLIDENE-D-GLUCONONITRLE
Document Type and Number:
Japanese Patent JPH01139594
Kind Code:
A
Abstract:

PURPOSE: To readily obtain the title nitrile useful as an intermediate for producing glucose labeled with an isotope in a short time by simple operation, by reacting an arabinose with a cyanogen compound expressed by the respective specific formulas.

CONSTITUTION: (A) 2,3:4,5-Di-O-isopropylidene-D-arabinose expressed by formula I is reacted with (B) an isotope-labeled cyanogen compound expressed by the formula R-*CN (*C is 11C, 13C or 14C; R is H or alkaline metal atom) to afford the aimed 3,4:5,6-di-O-isopropylidene-D-glucononitrile expressed by formula II. Furthermore, in the reaction, the compounds are preferably reacted in a mixed solvent of a dilute aqueous solution of, e.g., an alkali and methanol, at 0W50°C and pH 8W10.0 for 1W10min.


Inventors:
WATANABE MASAZUMI
Application Number:
JP1987000299009
Publication Date:
June 01, 1989
Filing Date:
November 26, 1987
Export Citation:
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Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
C07B59/00; A61K49/00; C07B31/00; C07C67/00; C07H1/00; C07H9/02; C07H9/04; (IPC1-7): A61K49/00; C07B59/00; C07H9/02
Attorney, Agent or Firm:
瀧野 秀雄 (外1名)



 
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