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Title:
PRODUCTION OF OPTICALLY ACTIVE 1-PHENYLETHANOL COMPOUND
Document Type and Number:
Japanese Patent JP2000256235
Kind Code:
A
Abstract:

To obtain in high optical yield the subject compound as a raw material compound for optically active forms of ketene S,S-acetals useful as antimycotic agents by reduction of an acetophenone derivative in the presence of a catalyst consisting of a complex of bisorganophosphorus-based compound and rhodium.

(C) This compound of formula IV (e.g. a compound of formula V) is obtained by reducing (A) a compound of formula I (R1 is H, halogen or the like; R2 is H, a 1-6C alkyl or the like; and (n) is 1-5) (e.g. 2,2',4'- trichloroacetophenone) in the presence of (B) a catalyst of formula II (R is a 1-6C alkyl, 3-8C cycloalkyl or 1-adamantyl group; and (n) is 1 or 2) (e.g. a compound of formula III) using a reducing agent such as ethylsilane or methylphenylsilane, pref. at -80 to room temperature; wherein the amount of the component B to be used is pref. 0.1-0.0001 wt.% based on the component A.


Inventors:
IMAMOTO TSUNEO
Application Number:
JP6172999A
Publication Date:
September 19, 2000
Filing Date:
March 09, 1999
Export Citation:
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Assignee:
NIHON NOHYAKU CO LTD
International Classes:
B01J31/24; C07B53/00; C07B61/00; C07C29/143; C07C33/46; (IPC1-7): C07C29/143; B01J31/24; C07C33/46
Attorney, Agent or Firm:
萼 経夫 (外2名)