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Title:
PRODUCTION OF OPTICALLY ACTIVE BENZYL GLYCIDYL ETHER
Document Type and Number:
Japanese Patent JPH0532649
Kind Code:
A
Abstract:

PURPOSE: To obtain an optically active benzyl glycidyl ether useful as an intermediate for optically active natural substance, etc., in high purity, simply.

CONSTITUTION: (A) An optically active 3-benzyloxy-1,2-propanediol shown by formula I (Ph is phenyl; *shows that carbon atom thereof is asymmetric carbon atom) is reacted with (B) a tetrahalogenomethane, especially carbon tetrachloride or carbon tetrabromide and (C) triphenylphosphine in an organic solvent (preferably aprotic solvent such as methylene chloride) preferably at 0-50°C, especially 10-40°C to give an optically active halogenohydrin derivatives shown by formula II-1 and formula II-2 (X is halogen). Then these derivatives are treated with a base, preferably an inorganic base such as KOH to suppress reduction in optical purity and to give optically active glycidyl ether shown by formula III in high purity and in high yield. The ratio of the components B and C based on the raw material A are preferably 1-5 equivalent, especially 1.02-1.15 equivalents, respectively.


Inventors:
TAKANO SEIICHI
SUGIHARA TAKUMICHI
KAMIKUBO TAKASHI
OGASAWARA KUNIRO
Application Number:
JP1991000280952
Publication Date:
February 09, 1993
Filing Date:
July 31, 1991
Export Citation:
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Assignee:
DAISO CO LTD
International Classes:
C07D301/26; C07B53/00; C07D303/18; C07D303/22; (IPC1-7): C07B53/00; C07D301/26; C07D303/18
Attorney, Agent or Firm:
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