PURPOSE: To obtain an aerosol of prostaglandin E1s (PGE1s) for external use, capable of keeping chemical stability of the PGE1s without inflicting pain on patients and capable of physiologically conforming to skin surfaces without damaging neogenetic skin surfaces, etc.
CONSTITUTION: An aerosol for external use comprising a fat emulsion of PGE1s containing one or more compounds selected from PGE1 and its derivatives (PGE1s) at a concentration of 0.1-500μg/ml, preferably 1-100/μg/ml in the fat emulsion. Since the aforementioned aerosol has various advantages in that high pharmacological effects can be expected with a small amount of aerosol; the aerosol can directly be administered to affected parts without touching the affected parts and various treatments can be carried out according to conditions of the affected parts, the aerosol can be utilized for various diseases such as burn, skin ulcer, bed sore and alopecia and its administration is extremely easy and effective. The aforementioned fatty emulsion is mainly composed of preferably 5-50% soybean oil, phospholipids in an amount of 1-50 pts.wt., preferably 5-30 pts.wt. based on 100 pts.wt. soybean oil and an adequate amount of water.
TAKADA ASAMI
NABETA KIICHIRO
