Title:
Pyrazolo pyrimidinyl inhibitor of ubiquitin activation enzyme
Document Type and Number:
Japanese Patent JP6122877
Kind Code:
B2
Abstract:
Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formulaor a pharmaceutically acceptable salt thereof, wherein Y isand W, Z, X, R, Rand Rare defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.
Inventors:
Afrose, roshan
Balasan, Induty.
Chavalli, Jeffrey Pee.
Fleming, Paul Yi.
Gorlin, Jeffrey Elle.
Girard, Mario
Langston, Stephen Pee.
Sorcy, Francois Earl.
Won, tu-chin
Yes, Intune
Balasan, Induty.
Chavalli, Jeffrey Pee.
Fleming, Paul Yi.
Gorlin, Jeffrey Elle.
Girard, Mario
Langston, Stephen Pee.
Sorcy, Francois Earl.
Won, tu-chin
Yes, Intune
Application Number:
JP2014557765A
Publication Date:
April 26, 2017
Filing Date:
February 14, 2013
Export Citation:
Assignee:
MILLENNIUM PHARMACEUTICALS, INC.
International Classes:
C07D487/04; A61K31/519; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| JP2010500353A | ||||
| JP2009528686A |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita