NEW MATERIAL:A compound (salt or ester) expressed by formula I [R1 is lower alkyl, phenyl, etc.; R2 is lower alkyl; R3 and R4 are H or lower alkyl; A is N or expressed by the formula C-R6 (R6 is H, methyl, etc.)] or formula II (R5 is H or lower alkyl; X is methylene, CO, O or S and Y is methylene when X ... Y is single bond and X and Y together form cis-vinylene when X ... Y is double bond).
EXAMPLE: 7-( cis-3-Amino-4-methoxy-1-pyrrolidinyl )-1-cyclopropyl-6-fluoro-1,4-di hydro-4-oxo-1,8-naphthyridine-3-carboxylic acid.hydrochloride.
USE: A remedy for microbism.
PREPARATION: For example, a 4-oxo-1,8-naphthyridine compound expressed by formula III (Z is halogen; R7 is methyl, etc.) is reacted with a 3-amino- pyrrolidine compound expressed by formula IV and the resultant product is then hydrolyzed to afford the aimed compound expressed by formula I.
KIMURA TOMIO
FUJIWARA YOSHIMI
KATSUBE TETSUTSUGU
NISHINO SHIGEYOSHI
UBE INDUSTRIES