NEW MATERIAL: A compound of formula I [wherein A, B, C and D are each H, a combination of A and B and a combination of C and D are each a carbonyl oxygen, at least one of the combination of A and B and the combination of C and D is a carbonyl oxygen and one of A and B, one of C and D are each H and the other are each OH; R1-R3 are each a halogen, trifluoromethyl, 1-4C alkyl, nitro, (substituted)amino, etc.; and R4 is H, 1-6C alkyl, 2-4C cyanoalkyl, etc.].
EXAMPLE: 1,2,3,6-Tetrahydro-1,3-dioxo-6-phenylpyrrolo[3,4-c]carbazole.
USE: A therapeutic drug for heart and cardiovascular diseases such as thrombosis, arteriosclerosis, hypertension, etc., inflammatory progression, allergy, cancer, denaturation and lesion of the central nervous system and virus infectious diseases.
PREPARATION: A 1-aryl-4-(2-nitroaryl)-1,4-butadiene of formula II is reacted with maleimide by addition cyclization to form a compound of formula III and this compound is dehydrogenated to form a compound of formula IV and this compound is reacted with a phosphorus (IV) compound.
YOHANESU HARUTENSHIYUTAIN
KURISUTOFU SHIEHITERE
KURAUSU RUDORUFU
DEIBITSUDO JIEEMUSU DOUURII
GIYUNTAA BAINHAIMAA
