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Title:
RADIOACTIVE PHARMACEUTICAL COMPOUND, DETECTION OF DENSITY OF TROPANE RECOGNITION SITE, MONITORING OF NEURODEGENERATION AND NEUROPSYCHIATRIC DISEASE, AND RADIOACTIVE PHARMACEUTICAL KIT
Document Type and Number:
Japanese Patent JP2000319201
Kind Code:
A
Abstract:

To obtain a new compound having high affinity for and an excellent selectivity to a dopamine transporter(DAT), capable of forming a complex labeled with radioactive substance 99mTc, and enabling the formed radioactive complex useful for detecting tropane recognition sites containing neurocytes such as a DAT when used as an imaging agent and for the early stage diagnosis and treatment of degenerative neuropathy.

This new compound is expressed by the formula [wherein R1 is an αor β-COORa (wherein Ra is a 1-5C alkyl or the like); R2 is an α- or β-C6H3XY (wherein X and Y are each Ra, H or the like); a bond between carbons at 2- and 3-positions is a single bond or a double bond; L is (CH2)n (wherein (n) is an integer of 1 to 6) or the like and; Ch is a tridentate or tetradentate ligand capable of forming a neutral complex labeled with technetium(Tc) or rhenium(Re)]. The compound is obtained e.g. by alkylating the chelating ligand with a haloalkylflate and then adding to an adequate nortropane. A radioactive substance for forming a complex is preferably Tc or Re.


Inventors:
MELTZER PETER C
MADRAS BERTHA K
BLUNDELL PAUL
MAHMOOD ASHFAQ
JONES ALUN G
FISCHMAN ALAN J
Application Number:
JP30959999A
Publication Date:
November 21, 2000
Filing Date:
October 29, 1999
Export Citation:
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Assignee:
HARVARD COLLEGE
ORGANIX INC
GEN HOSPITAL CORP
International Classes:
A61K31/46; A61K51/00; A61K51/04; A61P25/00; C07D451/02; A61P25/28; A61P43/00; C07F13/00; (IPC1-7): A61K51/00; C07D451/02
Foreign References:
WO1997016210A11997-05-09
Attorney, Agent or Firm:
Akinori Takano (2 outside)