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Title:
REDUCTION OF FLAKE-LIKE AGGREGATION IN NANOPARTICULATE ACTIVE AGENT COMPOSITIONS
Document Type and Number:
Japanese Patent JP2016053028
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method of reducing flake-like aggregation in nanoparticulate active agent compositions, and compositions obtained by the method.SOLUTION: The invention provides compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm. The active agent is applied to various drugs, but preferably is meloxicam.SELECTED DRAWING: None

Inventors:
RYDE NIELS P
PETER SNYDER
LIU WEI
DAVID M SLIFER
Application Number:
JP2015185009A
Publication Date:
April 14, 2016
Filing Date:
September 18, 2015
Export Citation:
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Assignee:
ALKERMES PHARMA IRELAND LTD
International Classes:
A61K9/08; A61K9/10; A61K31/5415; A61K45/08; A61K47/10; A61K47/26
Domestic Patent References:
JP2007511566A2007-05-10
JP2010513522A2010-04-30
JP6072539B22017-02-01
Foreign References:
WO2007135362A22007-11-29
WO2006088894A22006-08-24
WO2006108637A22006-10-19
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Ueda Wataru