REDUCTION OF FLAKE-LIKE AGGREGATION IN NANOPARTICULATE ACTIVE AGENT COMPOSITIONS

Title:

REDUCTION OF FLAKE-LIKE AGGREGATION IN NANOPARTICULATE ACTIVE AGENT COMPOSITIONS

Document Type and Number:

Japanese Patent JP2016053028

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a method of reducing flake-like aggregation in nanoparticulate active agent compositions, and compositions obtained by the method.SOLUTION: The invention provides compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm. The active agent is applied to various drugs, but preferably is meloxicam.SELECTED DRAWING: None

Inventors:

RYDE NIELS P
PETER SNYDER
LIU WEI
DAVID M SLIFER

Application Number:

JP2015185009A

Publication Date:

April 14, 2016

Filing Date:

September 18, 2015

Export Citation:

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Assignee:

ALKERMES PHARMA IRELAND LTD

International Classes:

A61K9/08; A61K9/10; A61K31/5415; A61K45/08; A61K47/10; A61K47/26

Domestic Patent References:

JP2007511566A	2007-05-10
JP2010513522A	2010-04-30
JP6072539B2	2017-02-01

Foreign References:

WO2007135362A2	2007-11-29
WO2006088894A2	2006-08-24
WO2006108637A2	2006-10-19

Attorney, Agent or Firm:

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Wataru Ueda

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