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Title:
S-ニトロソチオールを負荷した赤血球およびその使用
Document Type and Number:
Japanese Patent JP4262308
Kind Code:
B2
Abstract:
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.

Inventors:
Stanler, Jonathan S.
Bonaventure, joseph
Application Number:
JP51211197A
Publication Date:
May 13, 2009
Filing Date:
September 13, 1996
Export Citation:
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Assignee:
DUKE UNIVERSITY
International Classes:
A61K35/18; A61K31/00; A61K31/04; A61K31/095; A61K31/195; A61K31/198; A61K35/14; A61K38/00; A61K38/42; A61K47/48; A61P5/30; A61P5/42; A61P7/00; A61P7/06; A61P9/02; A61P9/10; A61P11/00; A61P31/00; C07K14/00; C12N5/08; G01N21/63; G01N21/76; G01N33/72
Domestic Patent References:
JP6506222A
Foreign References:
WO1993009806A1
WO1993012068A1
Attorney, Agent or Firm:
Yoshinori Hosoda