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Title:
SAMPLE MEASURING APPARATUS
Document Type and Number:
Japanese Patent JPH0545359
Kind Code:
A
Abstract:

PURPOSE: To separate coagulation of carrier particles to highly accurately measure immunological activation.

CONSTITUTION: A wedge-shaped transparent cover member 2 with a recess 2a provided at the center on an inner side is tightly attached on a flat substrate 1 formed of a. transparent member wherein a slit is formed by the recess 2a. Height of the slit between the recess 2a and the substrate 1 is designed to be reduced uniformly. Carrier particles F are sensitized with an immunological active substance, and when a reagent wherein the carrier particles F are dispersed in a liquid medium mainly comprising water is mixed with a sample, reaction occurs so that a plurality of immunological active substances and the carrier particles F form coagulated bodies G. If the reactant solution L is injected into the slit between the substrate 1 and the recess 2a, the reactant solution L enters toward a B direction where a vertical distance is narrow due to surface tension. Since non-coagulated carrier particles F are smaller in diameter, they can move into depth, while the coagulated bodies G are trapped in the midway and suspended depending on their size.


Inventors:
NISHIMURA MATSUOMI
TANAKA KAZUSANE
MIYAZAKI TAKESHI
ONISHI TOSHIICHI
TAKAYAMA HIDETO
Application Number:
JP1991000246929
Publication Date:
February 23, 1993
Filing Date:
August 30, 1991
Export Citation:
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Assignee:
CANON KK
International Classes:
G01N33/543; (IPC1-7): G01N33/543
Domestic Patent References:
JPS58755A1983-01-05
Attorney, Agent or Firm:
日比谷 征彦