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Title:
SHORT-ACTING DIHYDROPYRIDINE (CLEVIDIPINE) FOR USE IN REDUCING STROKE DAMAGE
Document Type and Number:
Japanese Patent JP2017095510
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a drug for lowering blood pressure which provides an optimal balance of efficacy, precision (titratability), and safety in stroke patients, especially acutely unstable patients.SOLUTION: The present invention relates to a method of reducing stroke damage and/or lowering blood pressure in a subject with stroke in need reducing stroke damage and/or lowering blood pressure, the method comprising a step of administering an effective amount of a pharmaceutical composition containing a short-acting dihydropyridine compound (preferably clevidipine or a pharmaceutically acceptable salt or ester thereof) to the subject. A related medicine and pharmaceutical composition and a method of producing the medicine are also provided.SELECTED DRAWING: None

Inventors:
GREGORY CHARLES WILLIAMS
Application Number:
JP2017012649A
Publication Date:
June 01, 2017
Filing Date:
January 27, 2017
Export Citation:
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Assignee:
CHIESI FARM SPA
International Classes:
A61K31/4422; A61K9/107; A61P9/00; A61P9/12
Foreign References:
WO2010014234A12010-02-04
Other References:
ERICKSON ABBIE L: "CLEVIDIPINE: A SHORT-ACTING INTRAVENOUS DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKER 以下備考", PHARMACOTHERAPY, vol. V30 N5, JPN5014005543, May 2010 (2010-05-01), pages 15 - 528
ERICSSON, ST-ERICCSON: "Mobility State Estimation consideration", 3GPP TSG-RAN WG2 #77BIS TDOC R2-121416, vol. V RAN WG2, JPN5016003214, 20 March 2012 (2012-03-20), pages 全文,全図
JPN. J. PHARMA. HEALTH CARE SCI., vol. 33, no. 5, JPN6016003216, 10 May 2007 (2007-05-10), JP, pages 463 - 468
医学と薬学, vol. 45, no. 2, JPN6016003218, February 2001 (2001-02-01), JP, pages 289 - 293
医学と薬学, vol. 45, no. 2, JPN6016003220, February 2001 (2001-02-01), JP, pages 295 - 301
PROG. MED., vol. 22, no. 4, JPN6016003223, April 2002 (2002-04-01), JP, pages 1047 - 1054
STROKE, vol. 38, no. 5, JPN6016003214, May 2007 (2007-05-01), pages 1655 - 1711
EXPERT OPINION ON PHARMACOTHERAPY, 2010.02, VOL. 11, NO. 2, PP. 281-295, JPN6018048042
MATTLE, H.P. ET AL.: "Blood Pressure and Vessel Recanalization in the First Hours after Ischemic Stroke", STROKE, vol. 36, no. 2, JPN6017034368, February 2005 (2005-02-01), pages 264 - 269
Attorney, Agent or Firm:
佐川 慎悟
小林 基子
川野 陽輔
江部 陽子
大窪 智行