Title:
【発明の名称】シアル酸グリコシド,抗原,免疫吸着剤およびそれらの調整方法
Document Type and Number:
Japanese Patent JP3083521
Kind Code:
B2
Abstract:
The stereochemistry of sialylation of an acceptor saccharide to obtain an alpha (2-3) or alpha (2-6) linkage is controlled to favor the alpha anomer by use of an aromatic ester of the sialyl reagent. The resulting intermediate alpha (2-3) and alpha (2-6) sialylated intermediate disaccharide blocks are useful in the synthesis of antigenic substances which can be used to raise antibodies useful in diagnosis and therapy, and can themselves be used as reagents in various applications. The preparation of the tetrasaccharide antigens corresponding to the 19-9 and sialyl-X antigens characteristic of malignant tissue illustrates the application of this method.
Inventors:
Murray Robert Ratcliff
Andre P. Venot
S. The Heer Abas
Andre P. Venot
S. The Heer Abas
Application Number:
JP30676588A
Publication Date:
September 04, 2000
Filing Date:
December 02, 1988
Export Citation:
Assignee:
Alberta Research Council
International Classes:
G01N33/53; A61K39/385; A61K47/48; B01J20/281; C07H3/06; C07H5/06; C07H7/027; C07H7/033; C07H11/04; C07H13/04; C07H15/04; C07H15/18; C07K1/113; C07K14/00; C07K14/76; C07K16/00; C07K16/28; C12Q1/48; G01N30/88; G01N33/531; G01N33/574; G01N33/66; (IPC1-7): C07H7/033; C07H15/04; C07K16/28; G01N33/53
Domestic Patent References:
| JP6112695A |
Other References:
J.AM.CHEM.SOC.=1986
THE JOURNAL OF BIOLOGICAL CHEMISTRY=1984
THE JOURNAL OF BIOLOGICAL CHEMISTRY=1986
THE JOURNAL OF BIOLOGICAL CHEMISTRY=1984
THE JOURNAL OF BIOLOGICAL CHEMISTRY=1986
Attorney, Agent or Firm:
Shusaku Yamamoto