Title:
SOLID MEDICINE CONTAINING ERYTHROMYCIN DERIVATIVE FOR ORAL ADMINISTRATION AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS6212717
Kind Code:
A
Abstract:
There is described a solid pharmaceutical preparation for oral administration which produces high and long-lasting blood and tissue levels, containing 9-deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)-ethylidene]oxy]-(9S)- erythromycin as active substance, in which the active substance must be intimately mixed with a basic excipient in a ratio of 1 mol of active substance to at least 2 gram-equivalents of basic excipient, and the preparations are coated with a gastric juice-resistant lacquer which is soluble in a pH range of between 5.5 and 6.8, and processes for preparing them. The solid pharmaceutical preparations include tablets, pellets or granules and a syrup can be produced from the latter.
Inventors:
ARAN ETEIAN
PEETAA GURUUBAA
URURITSUHI BUSUKU
PEETAA GURUUBAA
URURITSUHI BUSUKU
Application Number:
JP15991386A
Publication Date:
January 21, 1987
Filing Date:
July 09, 1986
Export Citation:
Assignee:
THOMAE GMBH DR K
International Classes:
A61K9/30; A61K9/16; A61K9/20; A61K9/22; A61K9/28; A61K9/50; A61K31/70; A61K31/7042; A61K31/7048; A61K47/02; A61P31/04; C07H17/08; (IPC1-7): A61K9/16; A61K9/30; A61K31/71; C07H17/08
Attorney, Agent or Firm:
Asamura Akira