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Title:
Stable intravenous preparation
Document Type and Number:
Japanese Patent JP6346945
Kind Code:
B2
Abstract:
A stable lyophilized formulation for intravenous administration of the compound 4-{[(2R, 3S, 55)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)- pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic Acid 1-[2-(2-methoxy-ethoxy)-ethoxycarbonyloxy]-ethyl ester is provided.

Inventors:
Galassau, Anthony N.
Inver, Petra
Kuresh, Farouk
Sunpat, Hallendra Earl.
Chan, Shanton
Application Number:
JP2016520502A
Publication Date:
June 20, 2018
Filing Date:
June 20, 2014
Export Citation:
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Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
International Classes:
A61K31/40; A61K9/19; A61K47/22; A61K47/26; A61P35/00
Domestic Patent References:
JP2013518921A
JP2006515855A
JP2013018737A
JP2015512890A
Foreign References:
WO2012177986A1
Other References:
日本臨牀,1989年 6月 1日,第47巻第6号,p.204(1412)-208(1416)
松田 芳久,製剤技術の基礎知識,医薬品添加剤要覧,武田 正三 株式会社薬業時報社,1992年11月25日,p.11-21
日本医薬品添加剤協会,医薬品添加物事典 2007,株式会社薬事日報社,2007年 7月25日,p.220-221
鈴木郁生 他,第十三改正 日本薬局方解説書,廣川書店,1996年,p.A112-A128
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation