Title:
混合された男性ホルモン及び黄体ホルモン特性を有するステロイド
Document Type and Number:
Japanese Patent JP2007515455
Kind Code:
A
Abstract:
The invention provides 19-nor-D-homosteroids, having a mixed androgenic/progestagenic profile, which are orally active, prevent trabecular bone mineral density (BMD) loss, and which lack liver toxicity, having a structure according to the formula (I) wherein, R1 is O, or NOR, with R being hydrogen, (C1-6)alkyl, or (C1-6)acyl, R2 is methyl or ethyl, and R3 is hydrogen or (C1-15)acyl.
Inventors:
Juan del Lau, Jap
Reisen, Derke
Grothen Heiss, Alley Yang
De Hoyer, Marcel Efert
Reisen, Derke
Grothen Heiss, Alley Yang
De Hoyer, Marcel Efert
Application Number:
JP2006546159A
Publication Date:
June 14, 2007
Filing Date:
December 15, 2004
Export Citation:
Assignee:
Akzo Novel N B
International Classes:
C07J63/00; A61K31/57; A61P5/24; A61P15/16
Foreign References:
| WO1985005361A1 | 1985-12-05 | |||
| US4788218A | 1988-11-29 | |||
| US3959322A | 1976-05-25 | |||
| WO1985005361A1 | 1985-12-05 | |||
| US4788218A | 1988-11-29 | |||
| US3959322A | 1976-05-25 |
Other References:
JPN6010063087, Ｓｔｅｒｏｉｄｓ, 1963, Ｖｏｌ．１, ｐ．３１７−３２４
JPN6010063088, Ｊ． Ｏｒｇ． Ｃｈｅｍ．, 1960, Ｖｏｌ．２５, ｐ．５８２−５８４
JPN6010063090, Ｔｅｔｒａｈｅｄｒｏｎ, 1964, Ｖｏｌ．２０, ｐｐ．１２７９−１２８８
JPN5006021088, Ｓ Ｎ ＡＮＡＮＣＨＥＮＫＯ, ＴＥＴＲＡＨＥＤＲＯＮ, 1962, Ｖ１８, Ｐ１３５５−１３６７, ＰＥＲＧＡＭＯＮ ＰＲＥＳＳ
JPN6010063088, Ｊ． Ｏｒｇ． Ｃｈｅｍ．, 1960, Ｖｏｌ．２５, ｐ．５８２−５８４
JPN6010063090, Ｔｅｔｒａｈｅｄｒｏｎ, 1964, Ｖｏｌ．２０, ｐｐ．１２７９−１２８８
JPN5006021088, Ｓ Ｎ ＡＮＡＮＣＨＥＮＫＯ, ＴＥＴＲＡＨＥＤＲＯＮ, 1962, Ｖ１８, Ｐ１３５５−１３６７, ＰＥＲＧＡＭＯＮ ＰＲＥＳＳ
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura