SUBSTITUTED PHENOL AND THIOPHENOL USEFUL AS ANTIOXIDANT AGENT

Japanese Patent JP2009132710

A

To provide a pharmaceutical composition for inhibiting cytokine-induced expression of vascular cell adhesion molecule-1 and/or intercellular adhesion molecule-1; and to provide a pharmaceutical composition for inhibiting chronic inflammatory disorders.

The pharmaceutical composition includes a compound represented by formula (1) wherein X is selected from a 5-10C branched alkyl or branched alkenyl group which may be substituted with a hydroxy group, Y represents a thio, oxy or methylene group, Z represents hydrogen or -C(O)-(CH2)m-Q, wherein Q represents hydrogen or -COOH, m is an integer 1, 2, 3 or 4; R1 represents a 1-6C alkyl; and R2, R3 and R4 each independently represent hydrogen or a 1-6C alkyl; or a stereoisomer thereof.

JP4913796	Crystal form of γ-aminobutyric acid analog
WO/1998/004513	WATER-MISCIBLE ESTERS OF MONOGLYCERIDES HAVING ANTIMICROBIAL ACTIVITY
WO/2020/247352	DELAYED RELEASE SOFTGEL CAPSULES

PARKER ROGER A
WRIGHT PAUL S
BUSCH STEVEN J
CHEN KIM S
YATES MARK T

JP2008295012A

June 18, 2009

November 19, 2008

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AVENTIS PHARMA INC

A61K31/225; A61K31/05; A61P3/10; A61K31/085; A61K31/10; A61K31/22; A61K31/222; A61P9/00; A61P9/10; A61P11/06; A61P19/02; A61P29/00; A61P35/00; A61P37/00; A61P37/06; C07C39/19; C07C43/23; C07C69/017; C07C69/035; C07C69/353; C07C323/20

JPS57176038A	1982-10-29
JPH072712A	1995-01-06
JPH0665115A	1994-03-08
JPH06206842A	1994-07-26

EP0589069A1

1994-03-30

Junji Yuda
Shoji Miwa
Noriyuki Takebayashi
Chika Takagi

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