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Title:
SUBSTITUTED PHENYL SULFONAMIDE AS SELECTIVE BETA 3 AGONIST FOR TREATMENT OF DIABETES AND OBESITY
Document Type and Number:
Japanese Patent JP2690006
Kind Code:
B2
Abstract:

PURPOSE: To provide substituted phenyl sulfonamides which is selective β3 adrenergic receptor agonists with very little β1 and β2 adrenergic receptor activity and having high activity in the treatment of Type II diabetes and obesity.
CONSTITUTION: The compound of formula [(n) is 0 to 7; (m) is 0, 1; (r) is 0 to 3; ring A is 5 to 6 heterocyclic ring with phenyl, naphytyl, 1 to 4 xenogenetic atoms (O, S, N), benzene ring fuse with 3-8C cycloalkyl ring or the like; R1 is OH, oxo, halogen, CN, NO2, NR8R8, SR8, alkyl, alkoxy or the like; R2 and R3 are each H, an alkyl; X is CH2, CH2-CH2, CH=CH or the like; R4 and R5 are each H, a halogen, alkyl, OR8 or the like; R6 is H, an alkyl; R7 is an alkyl, cycloalkyl or the like; R8 is H, an alkyl, cycloalkyl, phenyl or the like], for example, N-[4-[2-[[2-hydroxy-3-(4-hydroxyphenoxy) propyl]amino]ethil]phenyl]-benzensulfonamide is provided.


Inventors:
Michael H. Fisher
Robert Jay Masbink
Hiyun Oh Ok
Emma Earl Palmy
Ann E Weaver
Application Number:
JP1994000015323
Publication Date:
December 10, 1997
Filing Date:
February 09, 1994
Export Citation:
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Assignee:
Merck End-Campany Inc.
International Classes:
A61K31/18; A61K31/335; A61K31/34; A61K31/343; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/415; A61K31/42; A61K31/423; A61K31/425; A61K31/428; A61K31/433; A61K31/44; A61K31/4406; A61K31/4433; A61K31/47; A61K31/496; A61K31/505; A61K31/63; A61K31/635; A61P3/04; A61P3/08; A61P3/10; C07C311/02; C07C311/10; C07C311/13; C07C311/14; C07C311/21; C07C311/29; C07C311/44; C07C311/46; C07C311/47; C07D209/02; C07D209/08; C07D209/12; C07D209/34; C07D213/65; C07D213/71; C07D213/73; C07D213/75; C07D215/36; C07D233/54; C07D239/34; C07D261/20; C07D277/64; C07D277/74; C07D285/10; C07D285/14; C07D307/78; C07D307/79; C07D307/82; C07D311/08; C07D317/62; C07D319/18; C07D333/34; C07D333/54; C07D333/62; C07D401/12; C07D405/12; C07D409/04; C07D409/12; C07D413/12; C07D417/12; (IPC1-7): C07C311/21; C07C311/02; C07C311/10; C07C311/13; C07D209/02; C07D213/65; C07D213/71; C07D213/73; C07D213/75; C07D215/36; C07D233/54; C07D239/34; C07D261/20; C07D277/64; C07D285/10; C07D307/78; C07D333/34; C07D333/54; C07D333/62; C07D409/04
Domestic Patent References:
JP3501617A
Foreign References:
Other References:
J.MED.CHEM.,(1990),33(10),P.2883−91
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)