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Title:
SUBSTITUTION OF 3-FLUOROSULFONYLOXYCEPH-3-EM COMPOUND
Document Type and Number:
Japanese Patent JPH03220195
Kind Code:
A
Abstract:

NEW MATERIAL: A compound of formula I (Z is S, O, sulfoxide, sulfone or methylene; Q is H, an amino-protecting group, etc.; P is H, a carboxyl-protecting group or a physiologically hydrolyzable ester).

EXAMPLE: 7-Phenoxyacetamido-3-[(fluorosulfonyl)oxy]-ceph-3-em-4-carboxylic acid.

USE: Antibiotics.

PROCESS: A compound of formula II (L is fluorosulfonyloxy, etc.), is reacted with an organotin compound of the formula, R1-Sn-(R2)3 (R1 is H, 2-6C alkenyl, etc.; R2 is an organic group) in an inert protonic solvent in the presence of 1-10 mol.% of a Pd(II) or Pd(0) catalyst.


Inventors:
SUTEFUIN RICHIYAADO BEIKAA
CHIESUTAA SAPINO JIYUNIA
GUREGORII POORU ROOSU
Application Number:
JP1990000314479
Publication Date:
September 27, 1991
Filing Date:
November 21, 1990
Export Citation:
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Assignee:
SQUIBB BRISTOL MYERS CO (US)
International Classes:
C07D487/04; B01J23/44; B01J27/13; B01J31/12; B01J31/22; C07B61/00; C07D463/00; C07D501/00; C07D501/04; C07D501/20; C07D501/22; C07D501/59; C07D505/00; C07F7/22; (IPC1-7): B01J23/44; B01J27/13; B01J31/12; B01J31/22; C07B61/00; C07D487/04; C07D498/053; C07D501/04; C07D501/22; C07D501/59; C07F7/22