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Title:
SYNTHETIC METHOD AND INTERMEDIATE FOR POLYHYDROXY DIENYL LACTONE DERIVATIVE
Document Type and Number:
Japanese Patent JP2011046714
Kind Code:
A
Abstract:

To provide a lactone-containing compound such as discodermolides; a compound which mimics chemical and/or biological activity thereof; and a method and an intermediate, both of which are useful for producing the above compounds.

There are provided a compound which is based on a compound represented by figure, and is similar in having chemical and/or biological activity of discodermolides; an intermediates thereof; and production methods thereof. In the formula, R11 and R12 are each independently 1-10C alkyl; R14 and R15 are each independently an acid-instability protecting group; and R16 is selected from the group consisting of hydrogen and 1-6C alkyls.


Inventors:
SMITH AMOS B III
QIU YUPING
KAUFMAN MICHAEL
ARIMOTO HIROICHI
JONES DAVID R
KOBAYASHI KAORU
BEAUCHAMP THOMAS J
Application Number:
JP2010204706A
Publication Date:
March 10, 2011
Filing Date:
September 13, 2010
Export Citation:
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Assignee:
UNIV PENNSYLVANIA
International Classes:
C07D263/22; C07D309/30; A61K31/047; A61K31/12; A61K31/121; A61K31/27; A61K31/336; A61K31/351; A61K31/366; A61K31/422; A61K31/427; A61K31/5355; A61K31/7004; A61K31/7028; A61P35/00; A61P37/06; C07C29/38; C07C33/02; C07C33/42; C07C49/248; C07C239/06; C07C271/12; C07D303/16; C07D309/10; C07D309/32; C07D319/06; C07D407/06; C07D413/06; C07D413/12; C07D417/06; C07F7/18; C07F9/54; C07H1/00; C07H3/02; C07H23/00
Foreign References:
GB2280677A1995-02-08
Other References:
JPN6010012961; PATERSON, I., et al.: J. Chem. Soc., Chem. Commun. (24), pp.1790-1792 (1993)
JPN6010012962; SMITH, A.B., III, et al.: J. Am. Chem. Soc. 117(48), pp.12011-12012 (1995)
JPN6010012963; SMITH, A.B., III, et al.: Org. Lett. 1(11), pp.1823-1826 (1999)
JPN6010012964; FILLA, S.A.: 'Discodermolide synthesis: Fragments A and BCD' 海外博士論文 , pp.1-150 (1994), Massachusetts Institute of Technology
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takashi Nakata