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Title:
SYNTHETIC TECHNIQUE AND INTERMEDIATE OF POLYHYDROXY-DIENYL-LACTONE AND MIMIC THEREOF
Document Type and Number:
Japanese Patent JP2009102379
Kind Code:
A
Abstract:

To provide an improved synthetic method for preparing polyhydroxy-dienyl-lactone such as discodermolide, and to further provide a compound having the similar chemical and/or biological activity thereof.

The synthetic method is the one for the lactone-containing compound such as discodermolide. The compound which mimics the chemical and/or biological activity thereof and a method and an intermediate useful in its preparation are also provided.


Inventors:
SMITH AMOS B III
QIU YUPING
KAUFMAN MICHAEL
ARIMOTO HIROKAZA
JONES DAVID R
KOBAYASHI KAORU
Application Number:
JP2009002263A
Publication Date:
May 14, 2009
Filing Date:
January 08, 2009
Export Citation:
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Assignee:
UNIV PENNSYLVANIA (US)
International Classes:
C07D303/16; C07D407/06; A61K31/047; A61K31/12; A61K31/27; A61K31/336; A61K31/351; A61K31/366; A61K31/422; A61K31/427; A61K31/5355; A61K31/7028; A61P35/00; A61P37/06; C07C239/06; C07D263/22; C07D309/10; C07D309/30; C07D309/32; C07D319/06; C07D413/06; C07D413/12; C07D417/06; C07F7/18; C07H23/00
Foreign References:
Other References:
JPN6012017813; Journal of the American Chemical Society Vol.117, No.48, 1995, p.12011-12012
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita