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Title:
CD3/CD38 T-CELL RETARGETING HETERO-DIMERIC IMMUNOGLOBULINS AND METHODS OF THEIR PRODUCTION
Document Type and Number:
Japanese Patent JP2019214582
Kind Code:
A
Abstract:
To provide: hetero-dimeric immunoglobulins that target both a component of the human CD3 antigen and a component of the human CD38 antigen, and methods of making the same; and antibodies which bind to the human CD38 antigen and derivatives thereof for use as therapeutic or diagnostic reagents, and methods of making the same.SOLUTION: There is provided an antibody or fragment thereof that binds to human CD38 comprising a particular amino acid sequence. Further provided is a bispecific antibody comprising an antibody or fragment thereof that binds to human CD3 comprising a particular amino acid sequence.SELECTED DRAWING: None

Inventors:
ROMAIN OLLIER
SAMUEL HOU
RAMI LISSILAA
DARKO SKEGRO
JONATHAN BACK
Application Number:
JP2019135318A
Publication Date:
December 19, 2019
Filing Date:
July 23, 2019
Export Citation:
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Assignee:
GLENMARK PHARMACEUTICALS SA
International Classes:
C07K16/46; A61K39/395; A61K45/00; A61K47/68; A61P35/00; A61P35/02; C07K14/705; C07K16/28
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation