Title:
NY-ESO-1腫瘍抗原-HLA-A*02複合体に特異的なT細胞レセプター
Document Type and Number:
Japanese Patent JP2019504026
Kind Code:
A
Abstract:
本発明は、ガン抗原NY-ESO-1に由来するHLA-A*02制限ペプチドSLLMWITQCに結合するＴ細胞レセプター(TCR)に関する。前記TCRは、天然型NY-ESO-1 TCRに関して、α及び/又はβ可変ドメイン内に変異を含んでなり得る。本発明のTCRは、悪性疾患の治療用の新規な免疫療法剤としての使用に特に適切である。【選択図】図９
Inventors:
Chester, Fiona
Knox, Andrew Alexander
Rosa, jonathan patrick
Patel, Willen by Nabhai
Emma Elizabeth, Baston
Ruth Martinez, The Hague
Knox, Andrew Alexander
Rosa, jonathan patrick
Patel, Willen by Nabhai
Emma Elizabeth, Baston
Ruth Martinez, The Hague
Application Number:
JP2018532590A
Publication Date:
February 14, 2019
Filing Date:
December 22, 2016
Export Citation:
Assignee:
Immunocore Limited
International Classes:
C07K14/725; A61K31/7088; A61K39/395; A61K45/00; A61K47/66; A61K47/68; A61K48/00; A61P35/00; A61P43/00; C07K16/28; C07K19/00; C12N5/10; C12N15/62; C12N15/63
Domestic Patent References:
| JP2008509090A | 2008-03-27 | |||
| JP2007537743A | 2007-12-27 |
Foreign References:
| WO2014160030A2 | 2014-10-02 |
Other References:
CANCER IMMUNOL IMMUNOTHER, 2013, VOL.62, PP.773-785 AND SUPPLEMENTARY DATA, JPN6021000355, ISSN: 0004422817
NATURE MEDICINE, 2012, VOL.18, PP.980-988, JPN6021000357, ISSN: 0004422818
THE JOURNAL OF IMMUNOLOGY, 2008, VOL.180, PP.6116-6131, JPN6021000359, ISSN: 0004422819
NATURE MEDICINE, 2012, VOL.18, PP.980-988, JPN6021000357, ISSN: 0004422818
THE JOURNAL OF IMMUNOLOGY, 2008, VOL.180, PP.6116-6131, JPN6021000359, ISSN: 0004422819
Attorney, Agent or Firm:
Shintaro Nogawa
Shinji Kai
Yusuke Kaneko
Kiyoshi Inamoto
Masami Tomita
Shinji Kai
Yusuke Kaneko
Kiyoshi Inamoto
Masami Tomita