Title:
TRPM-2アンチセンス療法
Document Type and Number:
Japanese Patent JP4785252
Kind Code:
B2
Abstract:
A method for treating an individual suffering from a cancer comprising administering to the individual i) a chemotherapeutic agent, and ii) one antisense oligonucleotide having nucleotides in the sequence set forth in Seq. ID No. 4 and which antisense oligonucleotide has a phosphorothioate modification that increases the stability thereof in vivo, wherein the cancer expresses testosterone-repressed prostate message-2 (TRPM-2), thereby treating said individual.
Inventors:
Greaves, Martin
Rennie, Paul, S
Miyake, Hideaki
Nelson, Colleen
Rennie, Paul, S
Miyake, Hideaki
Nelson, Colleen
Application Number:
JP2000600553A
Publication Date:
October 05, 2011
Filing Date:
February 25, 2000
Export Citation:
Assignee:
The University of British Columbia
International Classes:
A61K48/00; A61K31/00; C12N15/09; A61K31/136; A61K31/337; A61K31/66; A61K31/704; A61K31/7105; A61K38/00; A61K41/00; A61K45/06; A61P5/24; A61P5/28; A61P35/00; A61P43/00; C07H21/00; C07K14/775; C12N15/113
Other References:
SENSIBAR,J.A. et al,Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin),Cancer Res,1995年,Vol.55, No.11,p.2431-7
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
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