Title:
テトラヒドロプロトベルベリン系化合物、その製造方法、使用及び医薬組成物
Document Type and Number:
Japanese Patent JP2020530483
Kind Code:
A
Abstract:
本発明は、一般式(I)で示されるテトラヒドロプロトベルベリン系化合物、そのエナンチオマー、ジアステレオマー、ラセミ体及びその混合物、並びにその薬理学的に許容される無機若しくは有機塩、結晶水和物及び溶媒和物を提供する。本発明は、さらに、前記化合物の製造方法、並びに中枢神経系疾患を予防及び/又は治療するための医薬の製造における使用を提供する。
Inventors:
Ho Yang
Thiane Cian Louis
Lee Chien Feng
One Yui
Wang Chen
Chen Weimin
Chu Fu Chian
Wu Chun Hoi
Chan Roncia
Shen Ching Shan
Thiane Hoalyan
Thiane Cian Louis
Lee Chien Feng
One Yui
Wang Chen
Chen Weimin
Chu Fu Chian
Wu Chun Hoi
Chan Roncia
Shen Ching Shan
Thiane Hoalyan
Application Number:
JP2020509452A
Publication Date:
October 22, 2020
Filing Date:
August 14, 2018
Export Citation:
Assignee:
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Top Harman Shanghai Company Limited
Top Harman Shanghai Company Limited
International Classes:
C07D455/03; A61K31/4375; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; C07D471/14; C07D498/14
Domestic Patent References:
JPS5295699A | 1977-08-11 | |||
JP2012513413A | 2012-06-14 | |||
JP2014515379A | 2014-06-30 |
Foreign References:
CN1900075A | 2007-01-24 | |||
CN105418601A | 2016-03-23 | |||
NL6501747A | 1965-08-16 | |||
WO2009002873A1 | 2008-12-31 | |||
US20090149488A1 | 2009-06-11 | |||
CN1900076A | 2007-01-24 |
Other References:
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富岡清, 人名反応に学ぶ有機合成の戦略, vol. 第1版第2刷, JPN6021013207, 30 March 2007 (2007-03-30), JP, pages 196 - 197, ISSN: 0004484527
辻二郎, 遷移金属が拓く有機合成 その多彩な反応形式と最新の成果, vol. 第1版, JPN6021013208, 1997, JP, pages 15 - 18, ISSN: 0004484528
CHEN, JICHAO; WANG, TIANYU; XU, SHENGTAO; LIN, AIJUN; YAO, HEQUAN; XIE, WEIJIA; ZHU, ZHEYING; XU, JI: "Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivative", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 132,, JPN6021013205, 2017, pages 173 - 183, ISSN: 0004484525
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富岡清, 人名反応に学ぶ有機合成の戦略, vol. 第1版第2刷, JPN6021013207, 30 March 2007 (2007-03-30), JP, pages 196 - 197, ISSN: 0004484527
辻二郎, 遷移金属が拓く有機合成 その多彩な反応形式と最新の成果, vol. 第1版, JPN6021013208, 1997, JP, pages 15 - 18, ISSN: 0004484528
CHEN, JICHAO; WANG, TIANYU; XU, SHENGTAO; LIN, AIJUN; YAO, HEQUAN; XIE, WEIJIA; ZHU, ZHEYING; XU, JI: "Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivative", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 132,, JPN6021013205, 2017, pages 173 - 183, ISSN: 0004484525
BARKOVIC, DRAGUTIN; GASPARAC, ZLATKO: "Semisynthetic berberine homologs. I. Ethers of berberrubine", FARMACEUTSKI GLASNIK, vol. 22(4),, JPN6021013206, 1966, pages 127 - 31, ISSN: 0004484526
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kumi Kitamura
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kumi Kitamura