Title:
ニューロキニン受容体アンタゴニストとしてのテトラヒドロピラン誘導体
Document Type and Number:
Japanese Patent JP2004518671
Kind Code:
A
Abstract:
The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7 and R8 represent a variety of substituents; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
Inventors:
Castro Pinero, Jose Lewis
Lavo, Biotor Antoni
Swain, Christopher Jiyoung
Lavo, Biotor Antoni
Swain, Christopher Jiyoung
Application Number:
JP2002557931A
Publication Date:
June 24, 2004
Filing Date:
January 16, 2002
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
A61K31/351; A61K31/41; A61K31/4196; A61K31/453; A61P1/08; A61P25/00; A61P25/06; A61P25/22; A61P25/24; A61P29/00; A61P43/00; C07D309/10; C07D405/06; (IPC1-7): C07D309/10; A61K31/351; A61K31/41; A61K31/4196; A61K31/453; A61P1/08; A61P25/00; A61P25/06; A61P25/22; A61P25/24; A61P29/00; A61P43/00; C07D405/06
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura