Title:
THIOL PROTECTING AGENT FOR CYSTEINE
Document Type and Number:
Japanese Patent JPH02221247
Kind Code:
A
Abstract:
NEW MATERIAL:N-Hydroxymethyltrimethylacetamide expressed by formula I.
USE: Capable of readily and nearly quantitatively protecting thiol of cysteine by reacting the compound expressed by formula I which is a thiol protecting agent for the cysteine with the cysteine at ambient temperature for 1hr and synthesizing S-trimethylacetamidomethyl-cysteine, having high stability to HF and alkalis and effectively utilized for synthesizing peptides having the cysteine.
PREPARATION: Trimethylacetamide expressed by formula II is reacted with formamide expressed by formula III in the presence of KOH to readily provide the compound expressed by formula I in good yield.
Inventors:
KISO YOSHIAKI
YOSHIDA MAKOTO
FUJIWARA YOICHI
KIMURA TORU
SHIMOKURA MASANORI
YOSHIDA MAKOTO
FUJIWARA YOICHI
KIMURA TORU
SHIMOKURA MASANORI
Application Number:
JP4393689A
Publication Date:
September 04, 1990
Filing Date:
February 23, 1989
Export Citation:
Assignee:
IWAI KAGAKU YAKUHIN KK
International Classes:
C07B51/00; C07C233/18; C07C323/58; C07C323/59; C07K1/06; C07K1/113; C07K14/00; C07K14/575; C07K14/58; (IPC1-7): C07B51/00; C07C233/18; C07C323/58; C07C323/59; C07K1/06; C07K7/10; C07K99/00
Attorney, Agent or Firm:
Kyozo Yuasa (4 outside)