Title:
BICYCLIC FUSED HETEROARYL OR ARYL COMPOUND AND USE THEREOF AS IRAK4 INHIBITOR
Document Type and Number:
Japanese Patent JP2017206549
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a compound that is useful for the treatment of autoimmune and inflammatory diseases associated with interleukin 1 receptor related kinase (IRAK).SOLUTION: Provided is a compound selected from: 7-methoxy-1-{[(1 S, 2S, 5R)-6-methyl-4-oxo-3-azabicyclo[3.1.0]hex-2-yl]methoxy}isoquinoline-6-carboxamide; 4-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-6-methoxyquinazoline-7-carboxamide; and 4-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-6-methoxyquinoline-7-carboxamide or the like, or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: None
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Inventors:
DAVID RANDOLPH ANDERSON
MARK EDWARD BUNNAGE
KEVIN JOSEPH CURRAN
CHRISTOPH MARTIN DEHNHARDT
LORI KRIM GAVRIN
JOEL ADAM GOLDBERG
HAN SEUNGIL
HEPWORTH DAVID
HUANG HORNG CHIH
ARTHUR LEE
KATHERINE LIN LEE
FRANK ELDRIDGE LOVERING
MICHAEL DENNIS LOWE
MATHIAS JOHN PAUL
NIKOLAOS PAPAIOANNOU
AKSHAY PATNY
BETSY SUSAN PIERCE
EDDINE SAIAH
JOSEPH WALTER STROHBACH
JOHN DAVID TRZUPEK
RICHARD VARGAS
WANG XIAOLUN
STEVEN WAYNE WRIGHT
CHRISTOPH WOLFGANG ZAPF
MARK EDWARD BUNNAGE
KEVIN JOSEPH CURRAN
CHRISTOPH MARTIN DEHNHARDT
LORI KRIM GAVRIN
JOEL ADAM GOLDBERG
HAN SEUNGIL
HEPWORTH DAVID
HUANG HORNG CHIH
ARTHUR LEE
KATHERINE LIN LEE
FRANK ELDRIDGE LOVERING
MICHAEL DENNIS LOWE
MATHIAS JOHN PAUL
NIKOLAOS PAPAIOANNOU
AKSHAY PATNY
BETSY SUSAN PIERCE
EDDINE SAIAH
JOSEPH WALTER STROHBACH
JOHN DAVID TRZUPEK
RICHARD VARGAS
WANG XIAOLUN
STEVEN WAYNE WRIGHT
CHRISTOPH WOLFGANG ZAPF
Application Number:
JP2017135751A
Publication Date:
November 24, 2017
Filing Date:
July 11, 2017
Export Citation:
Assignee:
PFIZER
International Classes:
C07D207/26; C07D401/12; C07D403/12
Domestic Patent References:
| JPH0245419A | 1990-02-15 | |||
| JP2005272474A | 2005-10-06 | |||
| JP2003504360A | 2003-02-04 | |||
| JPH04364156A | 1992-12-16 |
Foreign References:
| WO1997031006A1 | 1997-08-28 | |||
| EP1724268A1 | 2006-11-22 | |||
| US3673238A | 1972-06-27 | |||
| CN101353307A | 2009-01-28 |
Attorney, Agent or Firm:
Noh four