Title:
TIE2 ACTIVATOR, AGENT FOR BLOOD VESSEL MATURATION, BLOOD VESSEL STABILIZER, AND ORAL COMPOSITION FOR TIE2 ACTIVATION
Document Type and Number:
Japanese Patent JP2019023238
Kind Code:
A
Abstract:
To provide a Tie2 activator, a neovascularization inhibitor, an agent for blood vessel maturation, an agent for blood vessel normalization, and a blood vessel stabilizer which have an excellent Tie2 activating action, neovascularization inhibitory action, blood vessel maturation action, blood vessel normalization action, and blood vessel stabilization action, and have high safety, and to provide a pharmaceutical composition.SOLUTION: The invention provides a Tie2 activator, a neovascularization inhibitor, an agent for blood vessel maturation, an agent for blood vessel normalization, and a blood vessel stabilizer which contain as an active ingredient at least one selected from Tilia miqueliana extract, and Aesculus hippocastanum extract, and a pharmaceutical composition containing at least any of them.SELECTED DRAWING: None
Inventors:
KAWASHIMA YOSHIHITO
MIYAKE YASUO
OTO NOBUAKI
MIYAKE YASUO
OTO NOBUAKI
Application Number:
JP2018216916A
Publication Date:
February 14, 2019
Filing Date:
November 20, 2018
Export Citation:
Assignee:
MARUZEN PHARMA
International Classes:
A61K36/185; A61P9/00; A61P9/14; A61P43/00
Domestic Patent References:
| JP2013540788A | 2013-11-07 | |||
| JP2012116765A | 2012-06-21 | |||
| JPH02117619A | 1990-05-02 |
Other References:
薬理と治療, vol. 9(8), JPN6019050392, 1981, pages 209 - 218, ISSN: 0004264089
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, vol. 21, JPN6019050394, 1999, pages 437 - 447, ISSN: 0004264090
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, vol. 21, JPN6019050394, 1999, pages 437 - 447, ISSN: 0004264090
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda