Title:
【発明の名称】キノリジノン型化合物
Document Type and Number:
Japanese Patent JPH05503709
Kind Code:
A
Abstract:
Novel compounds are disclosed having formula (I) as well as pharmaceutically acceptable salts, esters and amides thereof, wherein R<1> is selected from (a) loweralkyl, (b) loweralkenyl, (c) halo(loweralkyl), (d) loweralkoxy, (e) cycloalkyl of from 3 to 8 carbons, (f) phenyl, (g) halo, (h) cyano, (i) nitro, (j) bicycloalkyl, (k) loweralkynyl, (l) alkoxycarbonyl, (m) nitrogen-containing aromatic heterocycle and (n) a group of the formula -NR<7>R<8>; R<2> is selected from the group consisting of halogen, loweralkoxy, carbocyclic aryloxy or carbocyclic aryl(loweralkyl)oxy, loweralkyl, loweralkenyl, cycloalkyl of from 3 to 8 carbons, cycloalkenyl of from 4 to 8 carbons, carbocyclic aryl(loweralkyl), cycloalkyl(loweralkyl), phenyl, amino, (loweralkyl)amino, carbocyclic aryl(loweralkyl)amino, hydroxy-substituted (loweralkyl)amino, nitrogen-containing aromatic heterocycle, bicyclic nitrogen-containing heterocycle and nitrogen-containing heterocycle having formula (II), wherein x is 0 to 3; R<9> is selected from (a)-(CH2)m-, wherein m is 1, 2 or 3, and (b) -(CH2)nR<10>(CH2)p-, wherein R<10> is selected from S, O and N, n is 1 or 2, and p is 1 or 2; and Y is a non-hydrogen substituent independently selected from loweralkyl, halo(loweralkyl), loweralkoxy, hydroxy-substituted loweralkyl, hydroxy, amino(loweralkyl), halogen and a group having the formula -NR<11>R<12>; R<3> is hydrogen, halogen or loweralkoxy; R<4> is selected from the group consisting of hydrogen, loweralkyl, a pharmaceutically acceptable cation and a prodrug ester group; R<5> is selected from the group consisting of hydrogen, halogen, hydroxy, loweralkyl, halo(loweralkyl), loweralkoxy and a group having the formula -NR<13>R<14>; and A is N or CR<6>, wherein R<6> is selected from hydrogen, halogen, loweralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy and amino(loweralkyl) or, alternatively, R<1> and R<6>, taken together with the atoms to which they are attached, form a 6-membered saturated ring which may contain an oxygen or a sulfur atom and which may be substituted with loweralkyl; with the proviso that when R<5> is hydrogen and A is CH then either (a) R<1> is NR<7>R<8>, or (b) R<2> is a group having formula (III), wherein x is 1-3 and R<9> and Y are as defined above.
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Inventors:
Chiyu, Daniel Tay
Lee, Chiuk M
Lee
Cooper, Kurt S
Plattner, Jei Kob Jei
Lee, Chiuk M
Lee
Cooper, Kurt S
Plattner, Jei Kob Jei
Application Number:
JP50915791A
Publication Date:
June 17, 1993
Filing Date:
May 01, 1991
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
A61K31/47; A61K31/505; A61K31/535; A61K31/54; A61P31/04; A61K31/435; C07D213/68; C07D455/02; C07D471/04; C07D471/08; C07D491/10; C07D491/16; C07D495/16; C07D519/00; C07K5/06; A61K38/00; (IPC1-7): C07D495/16; C07D491/16; C07D471/04; C07D455/02; A61K31/47; A61K31/435
Domestic Patent References:
| JPH01104014A | 1989-04-21 | |||
| JPS6277385A | 1987-04-09 | |||
| JPS60222482A | 1985-11-07 |
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)