Title:
TRICYCLIC CONDENSED PYRIMIDINE DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5555188
Kind Code:
A
Abstract:
NEW MATERIAL:A tricyclic condensed pyrimidine derivative of formula I (R1W3 are H, halogen, lower alkyl, etc.; R4 is H or lower alkyl; R5 is lower alkyl; A is C=C, C=N, or N=N, provided that one of the C atoms may be substituted by lower alkyl group) and its acid addition salt.
EXAMPLE: 4,5-Dihydro-4-etyl-5-hydroxy-5-phentyltetrazolo[1,5-a]quinazoline.
USE: Anti-phlogistic, analgesic agent.
PROCESS: The compound I can be prepared, e.g. by (1) reacting a compound II with a compound III [W is Li or MgX (X is halogen)] in an inert solvent at a temperature between room temperature and the refluxing temperature of the solvent, and (2) reacting the reaction mixture with water or a lower alkanol under cooling.
Inventors:
YAMAMOTO MICHIHIRO
KOSHIBA MASAO
YAMAMOTO HISAO
KOSHIBA MASAO
YAMAMOTO HISAO
Application Number:
JP12981178A
Publication Date:
April 22, 1980
Filing Date:
October 20, 1978
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO
International Classes:
C07D487/04; A61K31/505; A61P25/04; A61P29/00; (IPC1-7): A61K31/505; C07D487/04