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Title:
UNSATURATED LACTONE COMPOUND
Document Type and Number:
Japanese Patent JPH0770101
Kind Code:
A
Abstract:

PURPOSE: To provide a novel unsatd. lactone compd. which exhibits an action similar to that of nerve growth factor and an effect enhancing the action.

CONSTITUTION: This unsatd. lactone compd. is represented by the formula, is obtd. from a culture medium which is prepd. e.g. by inoculating and culturing Cladosporlum-cladosporiodies TF-0380 strain (FERM-P-13641) on an aseptic liq. culture medium comprising a carbon source (e.g. glucose), a nitrogen source (e.g. polypeptone or an yeast extract), and an inorg. salt (e.g. potassium phosphate or magnesium sulfate) and adjusted to a pH of about 6, and can be used as a medicine for improving or curing traumatic, drug-induced (such as alcohol- or carcinostatic-induced), and metabolic (such as inflammatory or diabetic) diseases, diseases accompanying to idiopathic peripheral nerve degeneration, and diseases accompanying to central nerve degeneration (such as Alzheimer- type or cerebrovascular dementia, Down's syndrome, or parkinsonism).


Inventors:
CHIN SOSHIYOU
KA HEKIBAI
ORII YURIKO
MIZOBE FUMIO
SAKAI NORIYOSHI
HANADA KAZUNORI
Application Number:
JP12161994A
Publication Date:
March 14, 1995
Filing Date:
June 03, 1994
Export Citation:
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Assignee:
KOKKA IYAKU KANRIKIYOKU SHISEN
TAISHO PHARMACEUTICAL CO LTD
International Classes:
A61P9/10; A61P25/00; A61P25/28; A61P43/00; C07D307/58; C12P17/04; A61K31/365; C12R1/645; (IPC1-7): C07D307/58
Attorney, Agent or Firm:
Kitagawa Fuzo