Title:
ヘッジホッグ経路関連障害の処置におけるビアリールカルボキサミドの使用
Document Type and Number:
Japanese Patent JP2009536156
Kind Code:
A
Abstract:
The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway. In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of the invention (e.g., a compound of Formula I).
Inventors:
Rishi Kumar Jane
Joseph Kelher The Third
Stephan Poikert
Sun In Chuan
Joseph Kelher The Third
Stephan Poikert
Sun In Chuan
Application Number:
JP2009505499A
Publication Date:
October 08, 2009
Filing Date:
April 12, 2007
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
A61K31/341; A61K31/166; A61K31/167; A61K31/18; A61K31/215; A61K31/27; A61K31/343; A61K31/36; A61K31/381; A61K31/40; A61K31/4045; A61K31/417; A61K31/4174; A61K31/4184; A61K31/42; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/47; A61P13/08; A61P17/00; A61P17/06; A61P19/10; A61P35/00; A61P43/00; A61P1/16; A61P7/00; A61P15/08; A61P17/14; A61P19/00; A61P25/00; C07C233/80; C07C271/20; C07C271/24; C07C307/08; C07C311/07; C07C311/20; C07D207/335; C07D209/14; C07D211/26; C07D213/38; C07D215/12; C07D233/61; C07D233/64; C07D235/14; C07D261/18; C07D277/28; C07D307/14; C07D307/18; C07D307/79; C07D307/81; C07D317/58; C07D333/20; C07D333/34
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi