Title:
【発明の名称】液胞型H▲上+▼ATPアーゼのインヒビターの使用
Document Type and Number:
Japanese Patent JPH08502725
Kind Code:
A
Abstract:
The activity of inhibitors of vacuolar-type H<+>-ATPases in the inhibition of vacuolation induced by Helicobacter pylori is disclosed. Preferred agents are the macrolide antibiotics bafilomycins A1, A2, B1, B2, C1, C2 and D, especially bafilomycin A1. The use of such compounds in the treatment of diseases, including peptic ulceration, is claimed.
Inventors:
Bunuri, Massimo
Montecucco, Cesare
Pappini, Emanuele
Rappoli, Reno
Montecucco, Cesare
Pappini, Emanuele
Rappoli, Reno
Application Number:
JP50587194A
Publication Date:
March 26, 1996
Filing Date:
August 11, 1993
Export Citation:
Assignee:
Biotine Esepee
International Classes:
A61K31/13; A61K31/16; A61K31/365; A61K31/40; A61K31/4015; A61K31/41; A61K31/415; A61K31/4245; A61K45/00; C07D271/12; A61P31/04; A61P43/00; C07D207/448; C07D313/00; C07D315/00; (IPC1-7): A61K45/00; A61K31/13; A61K31/365; A61K31/40; A61K31/41
Attorney, Agent or Firm:
Shusaku Yamamoto