Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
VACCINE COMPOSITION FOR INFECTION OF HELICOBACTER PYLORI
Document Type and Number:
Japanese Patent JP2000083671
Kind Code:
A
Abstract:

To obtain a new polypeptide having a same amino acid sequence with an associated antigen of Helicobacter pylori of a specific molecular weight or its mutated type amino acid sequence, showing a high eradication rate of a causing bacteria of a digestive tract and useful as a safe vaccine composition, etc.

This vaccine composition for an infection of Helicobacter pylori, is a new recombinant polypeptide having a same amino acid sequence with an associated antigen of Helicobacter pylori having approximately 20 kDa molecular weight or a mutated type amino acid sequence containing at least one mutation selected from s substitution, a deficiency, an addition or an insertion in the sequence, showing a high eradication rate of Helicobacter pylori which is considered to be a cause of digestive tract diseases such as gastritis, gastroduodenal ulcer, etc., useful as a production of a safe vaccine composition and used for the treatment of duodenal ulcer, gastritis, gastric ulcer, gastric cancer and gastric MALT lymphoma. The polypeptide is obtained by isolating a genom DNA from Helicobacter pylori, preparing an expression library, screening the same with an antigen, etc., and expressing the obtained gene.


Inventors:
MURAKAMI KAZUHISA
KOBAYASHI YOSHINAO
WAKATSUKI YOSHIO
Application Number:
JP1998000257343
Publication Date:
March 28, 2000
Filing Date:
September 11, 1998
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SHIONOGI & CO
International Classes:
C12N15/09; A61K39/106; A61P31/04; C07K14/195; G01N33/569; (IPC1-7): C12N15/09; A61K39/106; C07K14/195; G01N33/569
Attorney, Agent or Firm:
山内 秀晃