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Title:
VIRUS-LIKE PARTICLE VECTOR FOR DELIVERY OF PHARMACEUTICAL AGENTS, PROCESS FOR MANUFACTURE THEREOF, USES THEREOF AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
Japanese Patent JP2016053026
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a virus-like particle vector for the delivery of a therapeutic agent (a low-molecular weight agent) to a specific mammalian tissue, particularly a low-molecular weight anticancer agent to a cancer tissue.SOLUTION: The invention provides a polyvalent virus-like particle vector with at least two copies of an encapsulated or covalently linked low-molecular weight therapeutic substance, the vector constituting a recombinant adenoviral dodecahedron particle comprising a penton of adenovirus or a penton base protein of adenovirus, wherein the therapeutic substance is a proliferation inhibiting agent, preferably an anti-cancer drug. The adenoviral dodecahedron is derived from a mammalian particularly human virus, the low-molecular weight therapeutic substance to be delivered is a proliferation inhibiting agent, preferably a glycopeptide, in particular, an anti-cancer drug, preferably a bleomycin family, more preferably a bleomycin A5. Preferably, the low-molecular weight therapeutic substance is a particle covalently linked to an amine group or cysteine group or penton base of the dodecahedron using carbodiimide.SELECTED DRAWING: None

Inventors:
EWA SZOLAJSKA
JADWIGA CHROBOCZEK
MONIKA ZOCHOWSKA
Application Number:
JP2015179964A
Publication Date:
April 14, 2016
Filing Date:
September 11, 2015
Export Citation:
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Assignee:
INST BIOCHEMII I BIOFIZYKI PAN
International Classes:
A61K38/00; A61K9/16; A61K31/137; A61K31/198; A61K31/4409; A61K31/513; A61K35/761; A61K45/00; A61K47/42; A61K47/48; A61P11/06; A61P23/00; A61P25/28; A61P31/00; A61P31/04; A61P31/06; A61P33/02; A61P33/04; A61P35/00; C07K14/075; C12N7/01
Domestic Patent References:
JP2000500020A2000-01-11
JP2000500020A2000-01-11
JP2006504654A2006-02-09
JP2006504653A2006-02-09
JP2009510025A2009-03-12
JP2006504654A2006-02-09
JP2006504653A2006-02-09
JP2009510025A2009-03-12
Foreign References:
WO2005094878A12005-10-13
WO2004039406A12004-05-13
US20090022831A12009-01-22
Other References:
VIROLOGY, vol. 371, no. 1, JPN6014017181, 2008, pages 155 - 164
J. GEN. VIROL., vol. 87, no. 10, JPN6014017183, 2006, pages 2901 - 2905
J. MOL. BIOL., vol. 356, no. 2, JPN6014017186, 2006, pages 510 - 520
J. VIROL., vol. 77, no. 8, JPN6014017188, 2003, pages 4960 - 4964
NAT. BIOTECHNOL., vol. 15, no. 1, JPN6014017190, 1997, pages 52 - 56
ZOCHOWSKA MONIKA: "ADENOVIRUS DODECAHEDRON, AS A DRUG DELIVERY VECTOR", PLOS ONE, vol. V4 N5, JPN5012011914, May 2009 (2009-05-01)
Attorney, Agent or Firm:
Ippei Watanabe
Koike Shigeru