Title:
常磁性を有する水溶性高分岐ポリマー
Document Type and Number:
Japanese Patent JP5650993
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a highly-branched polymer which has sufficient relaxation capability, has no dissociation of metal ions, is excellent in living body safety, has moderate water solubility and lipid solubility and has wide in-organ distribution and an uptake effect in organs, thus enabling imaging of wide-ranging target organ and disorders and enabling use as a new MRI contrast agent.SOLUTION: There is provided a highly-branched polymer obtained by polymerizing the monomer A having an alkylene oxide group and two or more radically-polymerizing double bonds in the same molecule, and the monomer B having a portion expressing a paramagnetic property and at least one radically-polymerizing double bond in the same molecule, in the presence of a polymerization initiator C of 5-200 mol% with respect to the monomer A. The MRI contrast agent containing the polymer is also provided.
Inventors:
古賀 登
唐澤 悟
林 寛幸
平田 修
田中 章博
大土井 啓祐
唐澤 悟
林 寛幸
平田 修
田中 章博
大土井 啓祐
Application Number:
JP2010258958A
Publication Date:
January 07, 2015
Filing Date:
November 19, 2010
Export Citation:
Assignee:
国立大学法人九州大学
日産化学工業株式会社
日産化学工業株式会社
International Classes:
C08F290/06; A61B5/055
Attorney, Agent or Firm:
Sepal Tsuneo
Yoshio Miyazaki
Tsutomu Kato
Kyoko Koyama
伴 Tomoatsu
Yoshio Miyazaki
Tsutomu Kato
Kyoko Koyama
伴 Tomoatsu