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Title:
WIDE-RANGE PATHOLOGIC MODEL ANIMAL OF CARDIAC INFARCTION, METHOD FOR PREPARING THE SAME AND METHOD FOR SCREENING DRUG USING THE SAME MODEL ANIMAL
Document Type and Number:
Japanese Patent JP2002209473
Kind Code:
A
Abstract:

To overcome the problems that a model animal dies with a high probability by accompanying cardiac failure in prior art, effects of other organs should be consid ered in analysis and a wide-range model of cardiac infarction cannot be prepared, etc., and obtain the wide-range pathologic model animal of the cardiac infarction capable of separating a state of the cardiac failure and preparing the wide-range pathologic model of the cardiac infarction.

This wide-range pathologic model animal of the cardiac infarction is prepared by extracting the heart of a normal animal, carrying out ligating operation of the central part of the left coronary artery of the extracted heart, conducting ectopic transplantation of the heart subjected to the ligating operation to an abdominal part of another normal animal and providing the resultant animal subjected to the ectopic hear transplantion for the wide-range pathologic model animal of the cardiac infarction. The method for preparing the model animal is provided and the method for screening a drug is carried out by using the model animal. The wide-range pathologic model of the cardiac infarction is completed after the passage of three weeks from the transplantation.


Inventors:
NAKAMURA HIROSHI
MATSUZAKI MASUNORI
YOSHIDA TSUTOMU
Application Number:
JP2001000011866
Publication Date:
July 30, 2002
Filing Date:
January 19, 2001
Export Citation:
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Assignee:
YAMAGUCHI TECH LICENSING
BIOPHENIX KK
International Classes:
A01K67/027; A61D7/00; G01N33/15; G01N33/50; (IPC1-7): A01K67/027; A61D7/00; G01N33/15; G01N33/50
Attorney, Agent or Firm:
高木 義輝