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Title:
YopM AS DELIVERY VEHICLE FOR CARGO MOLECULES AND AS BIOLOGICAL THERAPEUTIC FOR IMMUNOMODULATION OF INFLAMMATORY REACTIONS
Document Type and Number:
Japanese Patent JP2015044826
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide new, effective and inexpensive immunosuppressants.SOLUTION: The present invention relates to the use of Yersinia outer protein M (YopM), a YopM fragment, or a YopM variant, which is capable of self-penetrating the cell membrane and of integrating into the cell cytosol without the requirement of additional factors for delivering a cargo molecule across the membrane to the cytosol of a cell. The present invention also relates to a pharmaceutical composition comprising YopM, a YopM fragment, or a YopM variant, which is capable of self-penetrating the cell membrane and of integrating into the cell cytosol without the requirement of additional factors for the regulation of inflammatory reactions of the immune system and the treatment of diseases caused by self-immunity of the host. The present invention further relates to a YopM fragment or variant, which is capable of self-penetrating the cell membrane and of integrating into the cell cytosol without the requirements of additional factors, as well as such proteins or YopM linked to a cargo molecule.

Inventors:
CHRISTIAN RUETER
GERHARD HEUSIPP
ALEXANDER M SCHMIDT
Application Number:
JP2014208689A
Publication Date:
March 12, 2015
Filing Date:
October 10, 2014
Export Citation:
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Assignee:
UNIVERSITAETSKLINIKUM MUENSTER
International Classes:
A61K47/48; A61K38/00; A61K38/16; A61K39/02; A61K45/00; A61K47/42; A61P1/00; A61P1/04; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P37/06; A61P37/08; C07K14/24; C12N15/09
Foreign References:
Other References:
JPN6013039110; BOLAND,A. et al: 'Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y.enterocolitica is internalized inside' The EMBO journal Vol.15, No.19, 1996, p.5191-201
JPN6016017398; 'Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of YopM, an' Acta crystallographica. Section D, Biological crystallography Vol. 56, No. Pt 1, 2000, pp. 1676-9
JPN6016017399; 'The Plague Virulence Protein YopM Targets the Innate Immune Response by Causing a Global Depletion o' Infect Immun Vol.72,No.8, 2004, pp.4589-4602
Attorney, Agent or Firm:
Seiji Ono
Reiko Tanaka
Matto valley Yuko
Kitano 健