Title:
α4介在細胞接着阻害剤
Document Type and Number:
Japanese Patent JP3634749
Kind Code:
B2
Abstract:
The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, -O- -(lower alkylene)-, etc.; n is 0, 1 or 2; Z is oxygen or sulfur; W is oxygen, sulfur, -CH=CH-, -NH- or -N=CH-; R<1>, R<2 >and R<3 >are the same or different and are hydrogen, halogen, hydroxyl, a substituted or unsubstituted lower alkyl gorup, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, etc.; R<4 >is tetrazolyl, carboxyl group, amide or ester; R<5 >is hydrogen, nitro, amino, hydroxyl, lower alkanoyl, lower alkyl, etc.; R<6 >is selected from (a) a substituted or unsubstituted phenyl group, (b) a substituted or unsubstituted pyridyl group, (c) a substituted or unsubstituted thienyl group, (d) a substituted or unsubstituted benzofuranyl group, etc.; or a pharmaceutically acceptable salt thereof.
Inventors:
Ira Sirker
Chris Jean S. Gudmundson
Richard Martin
Chris Jean S. Gudmundson
Richard Martin
Application Number:
JP2000540111A
Publication Date:
March 30, 2005
Filing Date:
January 19, 1999
Export Citation:
Assignee:
Tanabe Pharmaceutical Co., Ltd.
International Classes:
C07D295/02; A61K31/198; A61K31/223; A61K31/27; A61K31/275; A61K31/277; A61K31/34; A61K31/343; A61K31/352; A61K31/353; A61K31/381; A61K31/40; A61K31/415; A61K31/42; A61K31/426; A61K31/438; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/445; A61K31/4453; A61K31/495; A61K31/496; A61K31/4965; A61K31/505; A61K31/5375; A61K31/5377; A61K31/54; A61P1/00; A61P3/10; A61P11/06; A61P29/00; A61P43/00; C07C31/44; C07C233/51; C07C233/87; C07C235/52; C07C235/58; C07C235/84; C07C237/30; C07C237/32; C07C237/36; C07C237/42; C07C239/14; C07C251/40; C07C255/16; C07C255/57; C07C255/60; C07C271/28; C07C275/36; C07C275/42; C07C275/54; C07C311/08; C07C311/09; C07C311/16; C07C311/21; C07C311/29; C07C311/46; C07C311/51; C07C317/44; C07C317/50; C07C323/63; C07C335/22; C07D207/08; C07D207/27; C07D207/325; C07D207/327; C07D207/33; C07D207/333; C07D207/337; C07D207/34; C07D207/404; C07D211/22; C07D213/26; C07D213/30; C07D213/54; C07D213/56; C07D213/74; C07D213/81; C07D213/82; C07D231/12; C07D233/02; C07D233/72; C07D239/52; C07D241/12; C07D241/24; C07D257/02; C07D257/04; C07D261/08; C07D265/30; C07D277/18; C07D277/20; C07D277/22; C07D277/24; C07D277/30; C07D295/12; C07D295/13; C07D295/14; C07D295/155; C07D295/18; C07D295/185; C07D295/192; C07D307/79; C07D307/80; C07D307/81; C07D311/04; C07D311/58; C07D317/60; C07D319/18; C07D333/12; C07D333/16; C07D333/22; C07D333/24; C07D333/32; C07D333/34; C07D333/36; C07D333/38; C07D491/10; C07D491/113; C07D207/26; C07D207/32; C07D207/40; (IPC1-7): C07C233/87; A61K31/198; A61K31/27; A61K31/277; A61K31/34; A61K31/352; A61K31/381; A61K31/40; A61K31/415; A61K31/42; A61K31/426; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4453; A61K31/495; A61K31/5375; A61K31/54; A61P1/00; A61P3/10; A61P29/00; A61P43/00; C07C237/30; C07C275/36; C07C311/08; C07C311/16; C07C317/44; C07C323/63; C07C335/22; C07D207/08; C07D207/337; C07D207/34; C07D211/22; C07D213/30; C07D213/56; C07D231/12; C07D233/02; C07D241/24; C07D265/30; C07D277/18; C07D277/20; C07D277/24; C07D277/30; C07D295/12; C07D295/18; C07D307/80; C07D311/58; C07D333/24; C07D333/32; C07D333/34; C07D333/36; C07D491/113
Domestic Patent References:
| JP11505522A | ||||
| JP2001512134A | ||||
| JP2001517245A | ||||
| JP2002500232A | ||||
| JP2002512625A | ||||
| JP3101685A | ||||
| JP4275265A | ||||
| JP8231492A | ||||
| JP9087291A | ||||
| JP9118662A |
Foreign References:
| WO1995023222A1 | ||||
| WO1997024342A1 | ||||
| WO1997032874A1 | ||||
| WO1997042216A1 | ||||
| WO1998058950A1 | ||||
| DE3508251A1 |
Other References:
SOKOLOV,S.V. et al.,Derivatives of 1-phenyl-2,5-bis(chloromethyl)pyrrolidine.,Chemical Abstracts,1966年,Vol.65, 15302b-e
社団法人日本化学会,第4版実験化学講座22 有機合成IV -酸・アミノ酸・ペプチド-,丸善株式会社,1992年,第138~144頁
SHARP,M.J. et al.,SYNTHETIC CONNECTIONS TO THE AROMATIC DIRECTED METALATION REACTION. FUNCTIONALIZED ARYL BORONIC ACID,Tetrahedron Letters,1987年,Vol.28, No.43,p.5093-5096
BELETSKAYA,I.P. et al.,THE CROSS-COUPLING REACTIONS OF ORGANIC HALIDES WITH ORGANIC DERIVATIVES OF TIN, MERCURY AND COPPER ,Journal of Organometallic Chemistry,1983年,Vol.250,p.551-564
社団法人日本化学会,第4版実験化学講座22 有機合成IV -酸・アミノ酸・ペプチド-,丸善株式会社,1992年,第138~144頁
SHARP,M.J. et al.,SYNTHETIC CONNECTIONS TO THE AROMATIC DIRECTED METALATION REACTION. FUNCTIONALIZED ARYL BORONIC ACID,Tetrahedron Letters,1987年,Vol.28, No.43,p.5093-5096
BELETSKAYA,I.P. et al.,THE CROSS-COUPLING REACTIONS OF ORGANIC HALIDES WITH ORGANIC DERIVATIVES OF TIN, MERCURY AND COPPER ,Journal of Organometallic Chemistry,1983年,Vol.250,p.551-564
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Kyousei Tamura