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Title:
NMDA受容体拮抗剤としてのアミド誘導体
Document Type and Number:
Japanese Patent JP4225779
Kind Code:
B2
Abstract:
Compounds having NR2B selective NMDA receptor antagonist activity are disclosed of the formula (I) wherein one of the neighboring R1, R2, R3 and R4 groups is hydroxy, and the others are each hydrogen atoms, R5 and R6 together with the nitrogen between them form a saturated or unsaturated, 4-6 membered heterocyclic ring, which is substituted by phenoxy, phenyl-(C1-C4 alkyl), phenyl-(C1-C4 alkoxy), phenoxy-(C1-C4 alkyl), or benzoyl, optionally substituted on the aromatic ring by one or more halogen atoms, cyano or hydroxy groups, C1-C4 alkyl or C1-C4 alkoxy groups, X is NH-, Y is a nitrogen atom, or pharmaceutically acceptable salts thereof formed with acids or bases.

Inventors:
Cilla Holvato
Thunder falcus
Der Du Domainy
Istovan Bolza
Gizela Baltane Sarai
Youjeff Nadu
Sandor Korok
Application Number:
JP2002537711A
Publication Date:
February 18, 2009
Filing Date:
October 15, 2001
Export Citation:
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Assignee:
Richter Gedeon Vejesety Jar Erte
International Classes:
A61K31/454; A61K31/4439; A61P25/00; A61P25/02; A61P25/04; A61P43/00; C07D401/06; C07D403/06; C07D487/04; C07D498/04
Domestic Patent References:
JP7002770A
JP5320169A
JP7157487A
Foreign References:
WO1999001416A1
Other References:
Font M.,Indoles and pyridazino[4,5-b]indoles as nonnucleoside analog inhibitors of HIV-1 reverse transcriptase,European Journal of Medicinal Chemistry ,1995年,Vol.30,p.963-971
Attorney, Agent or Firm:
Mitsuo Tanaka
Misako Ohsaku
Nagatoshi Shinagawa



 
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