Title:
Antibodies that recognize deleted variants of the epidermal growth factor receptor, and their use
Document Type and Number:
Japanese Patent JP6328928
Kind Code:
B2
Abstract:
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
Inventors:
Richard Weaver
Xiao Feng
Orit Ford
Rally green
Gene Gudas
Bruce Quito
Ing Liu
Parani Rasana Swami
Robert Raya
Xiao Dong Young
Jose Corvallan
Ian Fortz
Xiao-Ji Jia
Jaspar can
Chadwick Tea King
Scott El Cracamp
Cao Juan Jane Su
Xiao Feng
Orit Ford
Rally green
Gene Gudas
Bruce Quito
Ing Liu
Parani Rasana Swami
Robert Raya
Xiao Dong Young
Jose Corvallan
Ian Fortz
Xiao-Ji Jia
Jaspar can
Chadwick Tea King
Scott El Cracamp
Cao Juan Jane Su
Application Number:
JP2013272028A
Publication Date:
May 23, 2018
Filing Date:
December 27, 2013
Export Citation:
Assignee:
Am Jien Fremont Incorporated
International Classes:
C12N15/09; A61K39/395; A61K47/48; A61P35/00; A61P43/00; C07K16/22; C07K16/28; C07K16/46; C07K17/00; C12N5/06; C12N5/10; C12N15/02; C12P21/08; G01N33/50; G01N33/53; G01N33/532; G01N33/574; G01N33/577; C12N
Domestic Patent References:
| JP5583560B2 | ||||
| JP4800210B2 |
Foreign References:
| WO1998050433A1 |
Other References:
Cancer Res.,1995年 7月15日,Vol.55, No.14,pp.3140-3148
Brain Tumor Pathol.,2000年,Vol.17, No.2,pp.71-78
Crit. Rev. Oncol. Hematol.,2001年 4月,Vol.38, No.1,pp.17-23
Int. J. Cancer,1993年,vol.55,pp.931-937
British Journal of Cancer,1995年,vol.71,pp.928-933
Brain Tumor Pathol.,2000年,Vol.17, No.2,pp.71-78
Crit. Rev. Oncol. Hematol.,2001年 4月,Vol.38, No.1,pp.17-23
Int. J. Cancer,1993年,vol.55,pp.931-937
British Journal of Cancer,1995年,vol.71,pp.928-933
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe