PURPOSE: To obtain PI3 kinase inhibiting agent useful as an antmtumor agent, anti-inflammatory agent and anti-arteriosclerotic agent by using a specific physiologically active quinone compound exhibiting PI3 kinase inhibiting action at a low concentration as an active component.
CONSTITUTION: This inhibiting agent contains a physiologically active quinone compound of the formula I (R is group of the formula II or III) as an active component. The compound of the formula I can be separated from a culture product obtained by culturing a microbial strain capable of producing the compound [preferably Drechslera sacchari D2597 (FERM P-13719)] preferably by surface culture method using an agar medium at 20-27°C. The inhibitor is administered preferably at a daily rate of 10-2,000mg of the physiologically active quinone compound for adult in 1-4 divided doses.
AZUMA KYOICHIRO
TAKASHIMA JUNKO
CHIBA NORIKO
YOSHIKAWA NOBUJI