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Title:
PI3 KINASE INHIBITOR AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH0725880
Kind Code:
A
Abstract:

PURPOSE: To obtain PI3 kinase inhibiting agent useful as an antmtumor agent, anti-inflammatory agent and anti-arteriosclerotic agent by using a specific physiologically active quinone compound exhibiting PI3 kinase inhibiting action at a low concentration as an active component.

CONSTITUTION: This inhibiting agent contains a physiologically active quinone compound of the formula I (R is group of the formula II or III) as an active component. The compound of the formula I can be separated from a culture product obtained by culturing a microbial strain capable of producing the compound [preferably Drechslera sacchari D2597 (FERM P-13719)] preferably by surface culture method using an agar medium at 20-27°C. The inhibitor is administered preferably at a daily rate of 10-2,000mg of the physiologically active quinone compound for adult in 1-4 divided doses.


Inventors:
OGAWARA HIROSHI
AZUMA KYOICHIRO
TAKASHIMA JUNKO
CHIBA NORIKO
YOSHIKAWA NOBUJI
Application Number:
JP16906693A
Publication Date:
January 27, 1995
Filing Date:
July 08, 1993
Export Citation:
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Assignee:
MITSUBISHI CHEM CORP
International Classes:
A61K31/35; A61P35/00; C07D493/04; C12N1/20; C12N9/99; C12P17/18; (IPC1-7): C07D493/04; A61K31/35; C12N1/20; C12N9/99; C12P17/18
Attorney, Agent or Firm:
Tsutomu Toyama (2 outside)



 
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