Title:
The benzimidazole carboxylic amide derivative as an APJ receptor modulator
Document Type and Number:
Japanese Patent JP6186438
Kind Code:
B2
Abstract:
The present invention relates to benzoimidazole-carboxylic acid amide compounds of the formula I, in which R′, R″, R′″, R1, R2, R3, R4, R5, R6 and Z are defined as indicated below. The compounds of the formula I are APJ receptor modulators, and are useful for the treatment of diseases associated with increased blood pressure for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
Inventors:
Stephanie Hachtel
Pauls Wohlfalt
John Weston
Marco Muller
Elizabeth Defosa
Katharina Melchu
The En-Hui Weng
Robert a binnie
Farid Abdul-Latif
William Jerome Bock
Armin Walzer
Pauls Wohlfalt
John Weston
Marco Muller
Elizabeth Defosa
Katharina Melchu
The En-Hui Weng
Robert a binnie
Farid Abdul-Latif
William Jerome Bock
Armin Walzer
Application Number:
JP2015532401A
Publication Date:
August 23, 2017
Filing Date:
September 19, 2013
Export Citation:
Assignee:
SANOFI
International Classes:
C07D235/08; A61K31/41; A61K31/4184; A61K31/422; A61K31/427; A61K31/4353; A61K31/4375; A61K31/439; A61K31/4545; A61K31/46; A61K31/4725; A61K31/497; A61K31/5377; A61K31/55; A61K31/551; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P27/02; A61P43/00; C07D403/06; C07D405/06; C07D409/06; C07D409/14; C07D413/14; C07D417/06; C07D417/14; C07D453/02; C07D455/02
Domestic Patent References:
| JP2002502844A | ||||
| JP2006527247A |
Foreign References:
| WO2003053938A1 | ||||
| EP1903052B1 |
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi
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