Title:
【発明の名称】APP修飾物質としてのベンゾジアゼピン誘導体
Document Type and Number:
Japanese Patent JP2003534333
Kind Code:
A
Abstract:
A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of beta-amyloid, such as Alzheimer's disease
Inventors:
Castro Pinero, Jose Lewis
Cheer Cheer, Ian
Giblin, Alexander Lichyard
Harrison, Tamothy
Keller, Sonia
Madein, Andrew
Alain Jiyoung, Nadein
Owens, Andrew Pate
Sparry, Timothy Theason
Taylor, Martin Lichyard
Williams, Susanna
Cheer Cheer, Ian
Giblin, Alexander Lichyard
Harrison, Tamothy
Keller, Sonia
Madein, Andrew
Alain Jiyoung, Nadein
Owens, Andrew Pate
Sparry, Timothy Theason
Taylor, Martin Lichyard
Williams, Susanna
Application Number:
JP2001586273A
Publication Date:
November 18, 2003
Filing Date:
May 21, 2001
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
A61K31/55; A61K31/5513; A61K31/5517; A61P25/28; C07D243/14; C07D243/22; C07D243/24; C07D401/04; C07D401/12; C07D403/04; C07D403/12; C07D405/04; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D413/04; C07D417/06; C07D417/12; C07D487/04; C07D491/10; (IPC1-7): C07D243/14; A61K31/5513; A61K31/5517; A61P25/28; C07D243/22; C07D243/24; C07D401/04; C07D403/04; C07D403/12; C07D405/04; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D413/04; C07D417/06; C07D417/12; C07D487/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)