Title:
マイトジェンにより活性化されるタンパク質に対するリン酸化酵素の活性を抑制するプロトベルベリン誘導体
Document Type and Number:
Japanese Patent JP2004503500
Kind Code:
A
Abstract:
The present invention relates to protoberberine derivatives which inhibit the activity of mitogen-activated protein kinase. More specifically, the present invention is directed to protoberberine derivatives which inhibit the activity of Wis1 and Spc1 kinase in intracellular signal transduction cascade wherein mitogen-activated protein kinase (MAPK) is involved.
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Inventors:
Song, Ki-won
Ja, Mi
Jean, Myeong-jin
Baek, Yun Ki
Kim, Jun-ho
Ja, Mi
Jean, Myeong-jin
Baek, Yun Ki
Kim, Jun-ho
Application Number:
JP2002510086A
Publication Date:
February 05, 2004
Filing Date:
June 14, 2001
Export Citation:
Assignee:
Hanwa Chemical Corporation
International Classes:
C07D455/03; A61K31/4375; A61K31/473; A61K31/4741; A61P31/10; A61P35/00; A61P43/00; (IPC1-7): A61K31/4375; A61P31/10; A61P35/00; A61P43/00; C07D455/03
Attorney, Agent or Firm:
Kenzo Hara
Ryuichi Kijima
Ichiro Kaneko
Ryuichi Kijima
Ichiro Kaneko