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Title:
c-fmsキナーゼの阻害剤
Document Type and Number:
Japanese Patent JP5480619
Kind Code:
B2
Abstract:
The invention is directed to compounds of Formula I: wherein Z, X, J, R 2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

Inventors:
イリグ,カール・アール
バレンタイン,シエリー・ケイ
チエン,ジンシエング
デスジヤーレイス,レネー・ルイーズ
メーガラ,サナス・ケイ
ウオール,マーク
ウイルソン,ケネス
Application Number:
JP2009506740A
Publication Date:
April 23, 2014
Filing Date:
April 18, 2007
Export Citation:
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Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D233/90; A61K31/4164; A61K31/4545; A61K31/496; A61K31/5377; A61K31/541; A61P1/04; A61P1/08; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P25/18; A61P25/28; A61P27/02; A61P29/00; A61P31/18; A61P35/00; A61P35/02; A61P35/04; A61P37/00; A61P43/00; C07D401/12; C07D401/14; A61K31/341; A61K31/40; A61K31/4025; A61K31/4178; A61K31/4439; A61K31/4525; C07D207/34; C07D235/24; C07D307/68; C07D403/12; C07D405/12
Foreign References:
WO2004096795A1
US20050131022
US20050113566
Attorney, Agent or Firm:
特許業務法人小田島特許事務所